While constipation gets more attention, diarrhea affects about 10-15% of GLP-1 users—especially during dose increases. Understanding why it happens and how to manage it can help you stay comfortable during treatment.
Why GLP-1s Can Cause Diarrhea
- • Changes in gut motility during adjustment period
- • Altered fat digestion
- • Dietary changes (eating less, different foods)
- • Individual response to medication
Managing GLP-1-Related Diarrhea
Avoid Trigger Foods
Fatty, greasy, and fried foods are common triggers. Spicy foods, caffeine, and alcohol can also worsen diarrhea. Stick to bland foods during flare-ups.
Stay Hydrated
Diarrhea can cause dehydration quickly. Drink plenty of water and consider electrolyte drinks if diarrhea persists. Watch for signs of dehydration.
Try the BRAT Diet
Bananas, rice, applesauce, and toast can help firm up stools. These bland foods are easy on the digestive system during flare-ups.
Consider Probiotics
Some people find probiotics help stabilize gut function. Look for strains like Saccharomyces boulardii, which is specifically studied for diarrhea.
When It's More Serious
Seek medical attention if you experience:
- • Diarrhea lasting more than 2-3 days
- • Signs of dehydration (dark urine, dizziness, dry mouth)
- • Blood in stool
- • Severe abdominal pain
- • Fever along with diarrhea
The Bottom Line
Diarrhea on GLP-1 medications is usually temporary and manageable. Avoid trigger foods, stay hydrated, and give your body time to adjust. Most people find GI symptoms improve within a few weeks at each dose level.