Constipation affects 20-30% of people on GLP-1 medications—making it one of the most common side effects after nausea. Understanding why it happens and how to manage it can help you stay comfortable during treatment.
Why GLP-1s Cause Constipation
- • Slowed gastric emptying means slower gut transit overall
- • Reduced food intake means less fiber and bulk
- • Dehydration from eating less and possible nausea
- • Changes in gut motility from the medication
Effective Strategies for Relief
Increase Fiber Intake
Aim for 25-30g of fiber daily. Even with reduced appetite, prioritize vegetables, fruits, and whole grains. Fiber supplements like psyllium husk can help if dietary fiber is difficult.
Stay Hydrated
Drink at least 8 glasses of water daily. Fiber without adequate water can worsen constipation. Set reminders if you're not feeling thirsty.
Move Your Body
Physical activity stimulates gut motility. Even a daily 20-minute walk can significantly improve bowel function.
Consider Safe Supplements
Magnesium citrate, docusate sodium (stool softener), and polyethylene glycol (MiraLAX) are generally safe options. Always check with your doctor first.
Establish a Routine
Try to have bowel movements at the same time daily—often 30 minutes after a meal when the gastrocolic reflex is active.
When to Seek Medical Help
Contact your healthcare provider if you experience:
- • No bowel movement for more than 3-4 days
- • Severe abdominal pain or bloating
- • Blood in stool
- • Vomiting with constipation
- • Constipation not improving with home remedies
The Bottom Line
Constipation on GLP-1 medications is common but manageable. Prioritize fiber, water, and movement. If home remedies don't help, safe over-the-counter options are available. Most people find constipation improves as the body adjusts to the medication.