Understanding when side effects typically occur—and when they resolve—helps you prepare for your GLP-1 journey and know when to seek medical attention.
Quick Reference
- • Most side effects occur during dose increases
- • GI symptoms usually improve within 4-8 weeks
- • Nausea is most common (40-50% of users)
- • Severe side effects are rare but require medical attention
Week-by-Week Timeline
Week 1-2: Initial Adjustment
Common: Mild nausea, decreased appetite, possible headache
What to expect: Your body is adjusting to the medication. Eat smaller meals and stay hydrated.
Week 3-4: Settling In
Common: Nausea often decreasing, constipation may appear
What to expect: Initial side effects start to fade. Increase fiber and water if constipated.
Dose Increase Periods
Common: Return of nausea, GI symptoms for 1-2 weeks
What to expect: Each dose increase may temporarily increase side effects. This is normal and usually resolves.
Month 2-3+: Stabilization
Common: Minimal ongoing side effects for most people
What to expect: Most users tolerate the medication well once at maintenance dose. Any persistent issues should be discussed with your doctor.
Warning Signs Requiring Medical Attention
Contact your doctor immediately if you experience:
- • Severe, persistent abdominal pain
- • Signs of pancreatitis (pain radiating to back)
- • Vision changes
- • Symptoms of allergic reaction
- • Signs of thyroid problems (neck lump, hoarseness)
- • Severe depression or suicidal thoughts
The Bottom Line
GLP-1 side effects typically follow a predictable pattern: worst during early weeks and dose increases, then improving over time. Most people tolerate the medication well once stabilized. Serious side effects are rare but require prompt medical attention.